ChromaDex Announces New Study Results Highlighting Promising Anti-Viral Effects of Niagen® in Coronavirus Animal Cell Model
A new preclinical study has completed, demonstrating a promising anti-viral effect of Niagen® in a Coronavirus animal cell model. Earlier research revealed up to an 80% depletion of the coenzyme NAD+ in Coronavirus infected cells. In this latest study, Coronavirus infected mouse cells treated with Niagen® had decreased viral replication compared to controls. This research is an important step towards understanding cells’ anti-viral response to this disease.
ChromaDex and the NIH-NIAID Rocky Mountain Laboratories Announce Study to Assess the Therapeutic Potential of Niagen® in COVID-19 Animal Models
ChromaDex and the National Institute of Allergy and Infectious Diseases (NIAID), a division of the National Institute of Health (NIH), announced the initiation of a preclinical study to assess the potential impact of Niagen® in animal models of COVID-19. The study on ChromaDex’s Niagen ingredient will be conducted at one of the few biosafety level four labs in the U.S.
What is a cGMP Facility?
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Companies that are committed to ethical and accurate product development generally conduct their production work in cGMP facilities. ‘cGMP’ stands for ‘Current Good Manufacturing Practice’ regulations.
The U.S Food and Drug Administration (FDA) created these regulations to ensure that products including food and beverages, dietary supplements, and pharmaceuticals are manufactured ethically and accurately. CGMPs entail the utilization of systems that establish and enforce appropriate design, monitoring, and control of manufacturing processes and facilities.
The U.S Food and Drug Administration (FDA) created these regulations to ensure that products including food and beverages, dietary supplements, and pharmaceuticals are manufactured ethically and accurately. CGMPs entail the utilization of systems that establish and enforce appropriate design, monitoring, and control of manufacturing processes and facilities.
The requirements
Adherence to cGMP regulations for dietary supplements assures the identity, strength, quality, and purity by requiring manufacturers to adequately control and document manufacturing operations. Acceptable observance of said regulations encompasses:
- Establishing strong management systems
- Obtaining quality raw materials
- Maintaining robust operating procedures
- Detecting product quality deviations
- Conducting reliable testing in laboratories
How does ChromaDex test?
ChromaDex, the manufacturers of Tru Niagen®, ensures the safety and accuracy of their products by testing for over 240 potential contaminants, including heavy metals, residual solvents, microbes, and other impurities. Their products go through a battery of 36 tests before it reaches consumer shelves.
The efficacy and strength of ChromaDex’s products are verified as accurate per label requirements.
Raw ingredients are tested in addition to the manufactured product, and product formulation goes back to the drawing board if any mistake is detected.
Though ChromaDex’s expert scientists can narrow the margin of manufacturing error down to an extremely low percentage, standards established by ChromaDex require development procedures to be recalibrated and improved anytime an abnormality arises, no matter how small.
Even the process of ensuring each bottle has the correct number of capsules is carried out fastidiously, with multiple evaluations conducted by multiple parties on every lot.
The efficacy and strength of ChromaDex’s products are verified as accurate per label requirements.
Raw ingredients are tested in addition to the manufactured product, and product formulation goes back to the drawing board if any mistake is detected.
Though ChromaDex’s expert scientists can narrow the margin of manufacturing error down to an extremely low percentage, standards established by ChromaDex require development procedures to be recalibrated and improved anytime an abnormality arises, no matter how small.
Even the process of ensuring each bottle has the correct number of capsules is carried out fastidiously, with multiple evaluations conducted by multiple parties on every lot.
ChromaDex and additional safety certifications
ChromaDex takes their safety certification process a step further than other supplement companies by having a legitimate third party annually assess their manufacturing practices.
Government inspections can occur as rarely as every five to seven years if a manufacturing facility is generally considered well-run. Other organizations often fill in the inspection gaps.
With quality being a strong business pillar, ChromaDex decided to partner with NSF International as its GMP auditor.
The NSF enforces standards across scientific industries to verify consumer safety. They dictate the ideal systems and procedures with sound science at the heart of their mission.
A track record of successful NSF audits serves as added credibility for companies who want to guarantee customers that their product is high quality and safe to use.
Government inspections can occur as rarely as every five to seven years if a manufacturing facility is generally considered well-run. Other organizations often fill in the inspection gaps.
With quality being a strong business pillar, ChromaDex decided to partner with NSF International as its GMP auditor.
The NSF enforces standards across scientific industries to verify consumer safety. They dictate the ideal systems and procedures with sound science at the heart of their mission.
A track record of successful NSF audits serves as added credibility for companies who want to guarantee customers that their product is high quality and safe to use.
Quality as a standard
When products are manufactured in a cGMP facility, consumers can feel confident that they meet premium standards.
ChromaDex continues to seek additional certifications to further bolster the confidence of their consumers. Among these are certifications issued by the International Organization for Standardization (ISO), plus Kosher and Halal organizations.
ChromaDex continues to seek additional certifications to further bolster the confidence of their consumers. Among these are certifications issued by the International Organization for Standardization (ISO), plus Kosher and Halal organizations.
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Tips For Overcoming Jet Lag
Are you going on holiday this summer? If you’re crossing time zones, you may be up against jet lag. There is all kinds of information out there about how to cope with the temporary sleep disorder, but how much of it is based on real science? Here's the science of jet lag and tips on how to manage it.
Get Outside Light is how our internal body clock senses what time it is and when to sync up with its other 24-hour cycle processes. Controlling when you’re exposed to light can help keep your internal clock in sync with its new environment. |
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Know It's Worse When Heading East
That common experience we have of one direction feeling harder to recover from than the other is real. Jet lag effects from eastward travel tend to last longer than those from traveling westward.
Get Your Day Drink On
This also isn't a general jet lap tip, but if you’re going to enjoy a drink in another time zone, it’s better to do it during the day. While alcohol can help us fall asleep faster, it also disrupts our overall quality and quantity of sleep. So shoot for an early afternoon drink instead of a late-night one.
Avoid Heavy Meals
Settling for a light meal on your first night in town may be worth it for a good night’s rest. Heavier meals are difficult to digest, and we don’t really want our cells working to turn food into energy while we’re trying to sleep. That can knock the rest of your 24-hour cycles out of sync and only add to the effects of jet lag.
Energize Your Cells
Just being in a different time zone can make you feel like you could use some more energy. So infuse your body with energy where it starts—your cells. TRU NIAGEN® increases cellular energy production, no matter which time zone you're in
That common experience we have of one direction feeling harder to recover from than the other is real. Jet lag effects from eastward travel tend to last longer than those from traveling westward.
Get Your Day Drink On
This also isn't a general jet lap tip, but if you’re going to enjoy a drink in another time zone, it’s better to do it during the day. While alcohol can help us fall asleep faster, it also disrupts our overall quality and quantity of sleep. So shoot for an early afternoon drink instead of a late-night one.
Avoid Heavy Meals
Settling for a light meal on your first night in town may be worth it for a good night’s rest. Heavier meals are difficult to digest, and we don’t really want our cells working to turn food into energy while we’re trying to sleep. That can knock the rest of your 24-hour cycles out of sync and only add to the effects of jet lag.
Energize Your Cells
Just being in a different time zone can make you feel like you could use some more energy. So infuse your body with energy where it starts—your cells. TRU NIAGEN® increases cellular energy production, no matter which time zone you're in
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NR (Nicotinamide Riboside): A Complete Guide To The Supplement For Mitochondrial Health & Longevity |
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By Stephanie Eckelkamp
Wellness Editor
MindBodyGreen
Wellness Editor
MindBodyGreen
Let's face it, just about everyone is looking for effective, science-backed ways to turn back the clock and boost longevity. So it's no wonder that anti-aging products and procedures—from stretch mark creams to antioxidant supplements to chemical peels to plastic surgery—have become a Billion Dollar industry (projected to hit $330 billion by 2021).
Much of what comprises this industry, however, simply hides aging from the outside—it doesn't actually counter the aging process on a cellular level from the inside out. There's no "fountain of youth" pill just yet.
But, it turns out, scientists do think they're getting closer to longevity in a capsule in the form of something called nicotinamide riboside (NR), which they're formulating into increasingly popular supplements that claim to boost energy and longevity, prevent disease, and slow the aging process.
Continue reading...
Much of what comprises this industry, however, simply hides aging from the outside—it doesn't actually counter the aging process on a cellular level from the inside out. There's no "fountain of youth" pill just yet.
But, it turns out, scientists do think they're getting closer to longevity in a capsule in the form of something called nicotinamide riboside (NR), which they're formulating into increasingly popular supplements that claim to boost energy and longevity, prevent disease, and slow the aging process.
Continue reading...
"NIAGEN® has a remarkable ability to boost NAD in tissues that need it"
– Charles Brenner, Ph.D.
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CHROMODEX CHIEF SCIENTIFIC ADVISOR LED THE DISCOVERY... |
In 2004, Dr. Charles Brenner discovered nicotinamide riboside (NR) could increase levels of a vital cellular resource. This resource is a central regulator in energy metabolism and is believed to play an important role in healthy human aging. Although NR is a naturally-occurring vitamin in milk, it’s only found in trace amounts. Based on Dr. Brenner’s patents and the established techniques of our parent company ChromaDex, NR was exclusively licensed and developed as NIAGEN®.
Continue reading...
In 2004, Dr. Charles Brenner discovered nicotinamide riboside (NR) could increase levels of a vital cellular resource. This resource is a central regulator in energy metabolism and is believed to play an important role in healthy human aging. Although NR is a naturally-occurring vitamin in milk, it’s only found in trace amounts. Based on Dr. Brenner’s patents and the established techniques of our parent company ChromaDex, NR was exclusively licensed and developed as NIAGEN®.
Continue reading...
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Stunning anti-ageing breakthrough could see humans live to 150 and regenerate organs by 2020 'for the price of a coffee a day'
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An extraordinary new anti-ageing technique could see humans live to 150 years old and allow them to regrow their organs by 2020.
Harvard Professor David Sinclair and researchers from the University of New South Wales developed the new process, which involves reprogramming cells.
Dr Sinclair said the technique could allow people to regenerate organs, and even allow paralysis sufferers to move again, with human trials due within two years.
The same researchers also found they could increase the lifespan of mice by ten per cent by giving them a vitamin B derivative pill.
Continue reading...
Harvard Professor David Sinclair and researchers from the University of New South Wales developed the new process, which involves reprogramming cells.
Dr Sinclair said the technique could allow people to regenerate organs, and even allow paralysis sufferers to move again, with human trials due within two years.
The same researchers also found they could increase the lifespan of mice by ten per cent by giving them a vitamin B derivative pill.
Continue reading...
